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Parallel construction of variable length Markov models for DNA sequences

J. Qvick

Master's Thesis, Chalmers University of Technology, Feb 2020.

Modern CPUs that contain multiple cores allows for parallel execution of algorithms, and while the technology exists it is not always used by existing implementations. Within this project one such case is investigated, namely the construction of variable length Markov models (VLMC). This work builds upon the unpublished work of J. Gustafsson, a base implementa- tion for the construction of VLMCs on DNA-sequences. In addition to implementing a parallel variant, the focus has also been on constructing models for large genomes, something not yet undergone within the base project. The report presents two po- tential practical parallel variants of this base, and early on selects the most promis- ing for further analysis. For this selected approach multiple tests are performed to present runtime, speedup and memory consumption. The load distribution is also analysed, and presents an opportunity for future improvement. The highest level of speedup was approximately a factor of 7, on 32 cores, compared to seriel execution. This test was performed with an input string of 22 GB. The memory footprint of the implementation, albeit high, is expected because of the adaptation to large input sizes.