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Efficient Computational Design of Tiling Arrays Using a Shortest Path Approach

A. Schliep and R. Krause

In Algorithms in Bioinformatics, Springer Berlin / Heidelberg, Volume 4645/2007, 383–394, 2007.

Genomic tiling arrays are a type of DNA microarrays which can investigate the complete genome of arbitrary species for which the sequence is known. The design or selection of suitable oligonucleotide probes for such arrays is however computationally difficult if features such as oligonucleotide quality and repetitive regions are to be considered.