Source:
@ARTICLE{Bredel2005,
author = {Markus
Bredel and Claudia Bredel and Dejan Juric and Griffith R Harsh and Hannes Vogel
and Lawrence D Recht and Branimir I Sikic},
title = {Functional
network analysis reveals extended gliomagenesis pathway maps and three novel
MYC-interacting genes in human gliomas.},
journal = {Cancer
Res},
year = {2005},
volume = {65},
pages = {8679--8689},
number = {19},
month = {Oct},
doi =
{10.1158/0008-5472.CAN-05-1204},
url =
{http://dx.doi.org/10.1158/0008-5472.CAN-05-1204}
}
Original data: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2223
Description:
The authors applied
refined network knowledge to the analysis of key functions and pathways
associated with gliomagenesis in a set of 50 human gliomas. For the analysis
of normal brain versus glioma subtypes, the authors grouped tumors into
31 pure glioblastomas (GBM) and 14 tumors with enrichment for oligodendroglial
morphology (OG). The cogrouping of pure oligodendroglial and mixed
oligoastroyctic tumor was based on an apparent coclustering of these
tumors in unsupervised, average-linkage hierarchical cluster
analysis. According to their analysis, three hundred fifty one
clones were revealed to be significantly linked to gliomagenesis: normal
brain versus all 50 gliomas --- 31
GBM, 14 OG, and five grade 1-3 astrocytomas (A).
Parameters used in our filter: