Source:

@ARTICLE{Alizadeh2000,

author = {A. A. Alizadeh and M. B. Eisen and R. E. Davis and C. Ma and I. S. Lossos and A. Rosenwald and J. C. Boldrick and H. Sabet and T. Tran and X. Yu and J. I. Powell and L. Yang and G. E. Marti and T. Moore and J. Hudson and L. Lu and D. B. Lewis and R. Tibshirani and G. Sherlock and W. C. Chan and T. C. Greiner and D. D. Weisenburger and J. O. Armitage and R. Warnke and R. Levy and W. Wilson and M. R. Grever and J. C. Byrd and D. Botstein and P. O. Brown and L. M. Staudt},

title = {Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling},

journal = {Nature},

year = {2000},

volume = {403},

pages = {503--511},

number = {6769},

month = {Feb},

url = {http://dx.doi.org/10.1038/35000501}

}

Original data: http://llmpp.nih.gov/lymphoma/analysis.shtml

Description:

The authors used microarray to characterize gene expression patterns of the three most prevalent adult lymphoid malignancies: Diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL). They further identified two molecularly distinct forms of DLBCL, which we will denote by DLBCL1 and DLBCL2.

From these, we formed three data sets with the following distribution of samples:

• Alizadeh-V1: 21 DLBCL1 and 21 DLBCL2
• Alizadeh-V2: 42 DLBCL, 9 FL and 11 CLL
• Alizadeh-V3: 21 DLBCL1, 21 DLBCL2, 9 FL and 11 CLL

Parameters used in our filter:

• Alizadeh-V1: l=4 and c=32
• Alizadeh-V2 and Alizadeh-V3: l=4 and c=47